The laminin–keratin link shields the nucleus from mechanical deformation and signalling

Nature Materials, Published online: 14 September 2023; doi:10.1038/s41563-023-01657-3

Laminin, an important component of the extracellular matrix supporting the epithelium, hinders the typical mechanoresponse of epithelial cells to an increase in substrate stiffness, by protecting the cell nucleus from mechanical deformation.Nature Materials, Published online: 14 September 2023; doi:10.1038/s41563-023-01657-3Laminin, an important component of the extracellular matrix supporting the epithelium, hinders the typical mechanoresponse of epithelial cells to an increase in substrate stiffness, by protecting the cell nucleus from mechanical deformation. Read More