Substrates mimicking the blastocyst geometry revert pluripotent stem cell to naivety

Nature Materials, Published online: 12 August 2024; doi:10.1038/s41563-024-01971-4

Substrates with blastocyst-like microstructures effectively revert primed pluripotent stem cells to naivety by promoting cell–cell apical constriction and mechanoinduced epigenetic activation of naive pluripotency genes.Nature Materials, Published online: 12 August 2024; doi:10.1038/s41563-024-01971-4Substrates with blastocyst-like microstructures effectively revert primed pluripotent stem cells to naivety by promoting cell–cell apical constriction and mechanoinduced epigenetic activation of naive pluripotency genes. Read More